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The virus interacts with the components and receptors of lipoproteins, which may lead to its development.Herpes transmission occurs between discordant partners; a person with a history of infection (HSV seropositive) can pass the virus to an HSV seronegative person.Herpes whitlow is a painful infection that typically affects the fingers or thumbs.On occasion, infection occurs on the toes or on the nail cuticle.This theory has been contested, however, since HSV is detected in large numbers of individuals having never experienced facial paralysis, and higher levels of antibodies for HSV are not found in HSV-infected individuals with Bell's palsy compared to those without.In the presence of a certain gene variation (APOE-epsilon4 allele carriers), HSV-1 appears to be particularly damaging to the nervous system and increases one's risk of developing Alzheimer's disease.

Herpetic sycosis is a recurrent or initial herpes simplex infection affecting primarily the hair follicle.

Herpes simplex virus 2 is typically contracted through direct skin-to-skin contact with an infected individual, but can also be contracted by exposure to infected saliva, semen, vaginal fluid, or the fluid from herpetic blisters.

To infect a new individual, HSV travels through tiny breaks in the skin or mucous membranes in the mouth or genital areas.

HSV is the most common cause of viral encephalitis.

When infecting the brain, the virus shows a preference for the temporal lobe.

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