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Some evolutionary gene modifications might prove fatal when exposed, but are nevertheless are useful while they remain dormant and hence are continued to be carried.For instance, Sickle Cell anemia is a fatal disease where RBCs sickle up causing life threatening complications.Tests are done during early stages of pregnancy, and if the mother is Rh -ve and the child is Rh ve, then an injection which prevents the mother’s immune system from generating antibodies against Rh D antigen is given during pregnancy.This will ensure that the fetus remains unaffected by the fact that the mother’s blood is Rh negative and ensures a safe delivery of the child.So, if the father is Rh positive and mother is Rh negative, then extra care should be taken during pregnancy.If the mother’s immune system has prior knowledge of Rh D antigen, either due to some previous blood transfusion of Rh ve blood group, or if this is not the first pregnancy and the earlier pregnancies carried a Rh positive child, then chances are that the mother’s immune system is already aware of Rh D antigen and has antibodies against it ready, which can be of an immediate concern for the fetus health.

So A ve means a blood group which has A antigen and Rh D antigen.However, the main Rh classification is based on one single antigen of special importance, called the D antigen.So, if your blood has the Rh D antigen, then your blood group is Rh positive, else it is Rh negative.The human immune system will attack any foreign substance entering the body by generating antibodies which will attack and destroy them.Hence, these substances which trigger antibody creation are called antigens.

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